Drinking two or more of any kind ofartificially sweetened drinks a day is linked to an increased risk of clot-based strokes, heart attacks and early death in women over 50, according to a new study by the American Heart Association and American Stroke Association.The risks were highest for women with no history of heart disease or diabetes and women who were obese or African-American.

Previous studies have focused on the bigger picture of cardiovascular disease,” said lead study author Yasmin Mossavar-Rahmani, an associate professor of clinical epidemiology and population health at the Albert Einstein College of Medicine in the Bronx, New York. “Our study focused on the most common type of stroke, ischemic stroke and its subtypes, one of which was small-vessel blockage. The other interesting thing about our study is that we looked at who is more vulnerable.”

After controlling for lifestyle factors, the study found that women who consumed two or more artificially sweetened beverages each day were 31% more likely to have a clot-based stroke, 29% more likely to have heart disease and 16% more likely to die from any causethan women who drank diet beverages less than once a week or not at all.

The analysis then looked at women with no history of heart disease and diabetes, which are key risk factors for stroke. The risks rose dramatically if those women were obese or African-American.

“We should be drinking more water and natural beverages, such as unsweetened herbal teas,” Mossavar-Rahmani said. “We can’t just go all day drinking diet soda. Unlimited amounts are not harmless.”

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